Diagnostic value of IgE antibodies to ω-5 gliadin, HMW-glutenin and gliadins in wheat challenged children
نویسندگان
چکیده
Background Wheat is one of the six most common foods causing allergy in children. Tests used in clinical practice to diagnose wheat allergy have limited value in predicting allergic reactions when eating wheat. A poor correlation between the outcome of oral wheat-challenges and the levels of IgE-antibodies (IgE-ab) to wheat has been observed. The wheat allergen ω-5 gliadin has been found to facilitate the diagnosis of wheat dependent exercise induced anaphylaxis (WDEIA) in adults and also wheat allergy in children.
منابع مشابه
Specific IgE determination to epitope peptides of omega-5 gliadin and high molecular weight glutenin subunit is a useful tool for diagnosis of wheat-dependent exercise-induced anaphylaxis.
Wheat omega-5 gliadin and a high m.w. glutenin subunit (HMW-glutenin) have been reported as major allergens in wheat-dependent exercise-induced anaphylaxis. A simultaneous detection of specific IgE to epitope sequences of both proteins is considered to be a reliable method for diagnosis of wheat-dependent exercise-induced anaphylaxis. However, the IgE-binding epitope of HMW-glutenin remains unk...
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BACKGROUND AND AIMS The ω-gliadin storage proteins of wheat are of interest in relation to their impact on grain processing properties and their role in food allergy, particularly the ω-5 sub-group and wheat-dependent exercise-induced anaphylaxis. The ω-gliadins are also known to be responsive to nitrogen application. This study therefore compares the effects of cultivar and nitrogen availabili...
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